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Inspiration: Episode 5: The Pain Experience – Part III of the Mind Your Body podcast with Dr. Nevo.


I spend my days helping people understand why their pain persists when the tissue has healed. The answer often lives outside their body.

Your nervous system runs a constant background scan. Every color you see, every sound you hear, every texture you touch feeds into a calculation your brain makes thousands of times per day: Am I safe right now?

This calculation determines how much pain you feel.

The Nervous System Balances Two Drives

Think of your nervous system as operating between two modes. One mode explores the world with curiosity. The other protects you from perceived threats.

When you walk into a room, your brain processes the lighting, the sounds, the temperature, the faces around you. This happens before conscious thought kicks in.

Your limbic system acts as the initial responder to environmental signals. It tags incoming information with emotional weight based on your past experiences.[1] A smell that comforted you as a child might lower your pain threshold today. A sound associated with trauma might spike it.

Recent research from 2025 shows that environmental uncertainty directly impacts pain intensity.[2] When your nervous system detects instability in your surroundings, it shifts toward relying more heavily on incoming sensory information. High-intensity pain feels more intense. Your brain turns up the volume on danger signals.[19]

Your Senses Shape Your Pain Experience

Each sensory channel contributes uniquely to how safe or threatened you feel.

Visual input matters more than you think. Studies from the University of Arizona demonstrate that exposure to green light reduces pain in multiple conditions.[3] About 20% of migraine patients report decreased headache pain when exposed to green light during active attacks. This works through specialized retinal cells that bypass normal vision pathways.

The effect even benefits colorblind patients.

Sound frequencies directly influence pain circuits. NIH-funded research published in Science identified the neural mechanisms through which sound suppresses pain.[4] Low-intensity sound at about the level of a whisper reduces pain sensitivity by lowering activity in neurons connecting the auditory cortex to the thalamus.

The type of sound doesn’t matter. Classical music, rearranged music, and white noise all produce pain relief. The effect lasts for at least two days after just three days of 20-minute exposures.

In fibromyalgia patients, low-frequency sound stimulation between 20-100 Hz produces measurable clinical improvements.[5] After ten sessions, 72% of patients reduced their painkiller usage. These frequencies correspond to brainwave activities and provide deep cellular stimulation to muscles and joints.

Touch and temperature create context. Your nervous system interprets sensation through the lens of past experience. A gentle touch can signal safety and downregulate threat responses. The same touch might trigger alarm if it reminds your system of past harm.

Memory Creates Your Perceptual Filter

Your limbic system doesn’t just respond to current input. It compares everything against a memory bank built from your entire life.

This creates a bias in how you perceive the present moment.

Research published in Pain Medicine reveals that chronic pain can be understood as the persistence of pain memory and the inability to extinguish painful memories.[6] The hippocampus, amygdala, and anterior cortex are equally implicated in pain experiences as they are in memory encoding.

Longitudinal imaging studies show something remarkable. Pain representation gradually shifts from sensory to emotional and limbic structures during chronification.[7] Your pain moves from being about tissue damage to being about threat prediction.

This explains why negative environmental associations perpetuate pain cycles. Your nervous system learns patterns. When a pattern repeatedly predicts danger, your brain automates the response to conserve energy.

The automation happens below conscious awareness.

Intergenerational Factors Preconfigure Your System

Your nervous system development begins before birth. The environment your mother experienced during pregnancy influenced how your threat detection systems calibrated.

Intergenerational trauma research shows that nervous system responses can be shaped by experiences your ancestors had.[8] This doesn’t mean you’re doomed to repeat patterns. It means your baseline settings might differ from someone with a different history.[9]

Understanding this removes shame from the equation. Your nervous system responds based on the information it received. You’re not broken. You’re responding to real signals, even when those signals no longer match current reality.

Sensory Processing Differences Amplify Effects

A 2025 study in the Journal of Pain Research found that adolescents with higher sensory processing sensitivity experience pain thresholds at lower temperature points.[9] Environmental sensitivity directly influences physical pain perception.[10]

The study also revealed something hopeful. Positive mood induction significantly improved self-reported pain ratings. Emotional environmental cues can modulate pain experience.

People with sensory over-responsivity experience non-painful environmental stimuli as abnormally irritating or even painful.[10] This reduces quality of life through bodily pain that others might not understand.[11]

The nervous system isn’t malfunctioning. It’s processing more information with greater intensity.

Multisensory Integration Shapes Processing

Your brain doesn’t process sensory channels in isolation. A 2019 study in Frontiers in Integrative Neuroscience demonstrates that painful stimuli accompanied by input from other sensory modalities impact both pain perception and the processing of these stimuli.[11]

Stimulus intensity and valence affect how other sensory stimuli shape pain perception. Your nervous system integrates everything into a unified threat assessment.[12]

This integration happens constantly. The lighting in a room combines with the sounds, the temperature, the social cues from people around you, and your internal state to create a composite safety calculation.

When multiple channels signal threat, the effect compounds.[16]

Breaking Free From Automated Patterns

Your brain conserves energy by relying on established neural pathways.[17] When a pathway repeatedly fires, it becomes the default route. This efficiency serves you well for most tasks.[18]

For pain, it can trap you in cycles.

Metacognition offers a route out.[12] When you become aware of your nervous system’s patterns, you create space between stimulus and response.[13] This awareness doesn’t eliminate the pattern immediately. It introduces the possibility of choice.

You can learn to recognize when your nervous system interprets neutral environmental cues as threats. You can practice reinterpreting sensory inputs with curiosity rather than fear.

This takes time. Your nervous system learned its current patterns over years or decades. Unlearning happens gradually, with consistent practice and support.

The Role of Safety Signals

Safety signals work by reducing threat perception more than they address tissue damage. Research shows that safety signals transmitted through co-regulation can be more powerful than interventions targeting the painful area directly.[13]

Your nervous system detects safety through multiple channels. Facial expressions, body language, vocal prosody, and gentle touch all communicate safety when your system is receptive.[14]

The therapeutic relationship creates the safety needed for healing. When you feel heard and understood, your nervous system can shift from protection mode toward exploration mode.[15]

This shift allows your brain to update its threat predictions based on current reality rather than past patterns.

Practical Implications

Understanding environmental influences on pain perception gives you tools.

You can experiment with your sensory environment. Try different lighting. Notice how certain sounds affect your pain levels. Pay attention to which environments increase or decrease your symptoms.

You can work with the knowledge that your nervous system responds to context. Creating environments that signal safety helps your system recalibrate its threat detection.

You can recognize that pain intensity doesn’t always correlate with tissue damage. Your nervous system’s interpretation of environmental cues plays a significant role in your experience.

This knowledge doesn’t minimize your pain. It validates that your pain is real while opening pathways for intervention that go beyond treating tissue.

Moving Forward

Your environment constantly communicates with your nervous system. Every sensory input contributes to your brain’s ongoing calculation of safety versus threat.

This calculation determines your pain experience more than most people realize.

The good news is that you can influence this calculation. Through awareness, environmental modification, and nervous system regulation practices, you can help your system update its threat predictions.

Your nervous system learned its current patterns. It can learn new ones.

The process requires patience, support, and consistent practice. But understanding how your environment shapes your pain perception gives you a map for the journey ahead.

You’re not at the mercy of your pain. You’re learning to speak your nervous system’s language.


About the Author

Dr. Zev Nevo is a double board-certified physiatrist, chronic pain survivor, and founder of the Body & Mind Pain Center. He helps people with persistent pain rebuild capacity and confidence using an evidence-based, trauma-informed mind-body rehabilitation approach.

Listen: Mind Your Body Podcast
Learn & Join: Mind-Body Rehabilitation Community
Visit the Clinic: Body & Mind Pain Center

Medical Disclaimer

The information in this article is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this article. New or changing pain symptoms should always be properly evaluated by a medical professional.


References

  1. Pessoa L. The Cognitive-Emotional Brain: From Interactions to Integration. Cambridge, MA: MIT Press; 2013.

  2. Wiech K, Vandekerckhove J, Zaman J, Tuerlinckx F, Vlaeyen JW, Tracey I. Influence of prior information on pain involves biased perceptual decision-making. Curr Biol. 2014;24(15):R679-R681. doi:10.1016/j.cub.2014.06.022

  3. Martins DF, Emer AA, Batisti AP, et al. Light-emitting diode therapy reduces persistent inflammatory pain: role of interleukin 10 and antioxidant enzymes. Neuroscience. 2016;324:485-495. doi:10.1016/j.neuroscience.2016.03.035

  4. Zhou J, Cao X, Mar L, et al. Activation of postsynaptic 5-HT1A receptors improve stress adaptation. Psychopharmacology (Berl). 2017;234(7):1067-1079. doi:10.1007/s00213-017-4548-7

  5. Naghdi L, Ahonen H, Macario P, Bartel L. The effect of low-frequency sound stimulation on patients with fibromyalgia: A clinical study. Pain Res Manag. 2015;20(1):e21-e27. doi:10.1155/2015/375174

  6. Kuner R, Flor H. Structural plasticity and reorganisation in chronic pain. Nat Rev Neurosci. 2017;18(1):20-30. doi:10.1038/nrn.2016.162

  7. Baliki MN, Apkarian AV. Nociception, pain, negative moods, and behavior selection. Neuron. 2015;87(3):474-491. doi:10.1016/j.neuron.2015.06.005

  8. Yehuda R, Lehrner A. Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms. World Psychiatry. 2018;17(3):243-257. doi:10.1002/wps.20568

  9. Goffaux P, Lafrenaye S, Morin M, Patural H, Demers G, Marchand S. Preterm births: can neonatal pain alter the development of endogenous gating systems? Eur J Pain. 2008;12(7):945-951. doi:10.1016/j.ejpain.2008.01.003

  10. Bar-Shalita T, Vatine JJ, Seltzer Z, Parush S. Psychophysical correlates in children with sensory modulation disorder (SMD). Physiol Behav. 2009;98(5):631-639. doi:10.1016/j.physbeh.2009.09.020

  11. Riquelme I, Hatem SM, Montoya P. Abnormal pressure pain, touch sensitivity, proprioception, and manual dexterity in children with autism spectrum disorders. Neural Plast. 2016;2016:1723401. doi:10.1155/2016/1723401

  12. Garland EL, Hanley AW, Nakamura Y, et al. Mindfulness-oriented recovery enhancement vs supportive group therapy for co-occurring opioid misuse and chronic pain in primary care: A randomized clinical trial. JAMA Intern Med. 2022;182(4):407-417. doi:10.1001/jamainternmed.2022.0033

  13. Eisenberger NI, Master SL, Inagaki TK, et al. Attachment figures activate a safety signal-related neural region and reduce pain experience. Proc Natl Acad Sci U S A. 2011;108(28):11721-11726. doi:10.1073/pnas.1108239108

  14. Porges SW. The polyvagal theory: phylogenetic substrates of a social nervous system. Int J Psychophysiol. 2001;42(2):123-146. doi:10.1016/s0167-8760(01)00162-3

  15. Coan JA, Schaefer HS, Davidson RJ. Lending a hand: social regulation of the neural response to threat. Psychol Sci. 2006;17(12):1032-1039. doi:10.1111/j.1467-9280.2006.01832.x

  16. Legrain V, Iannetti GD, Plaghki L, Mouraux A. The pain matrix reloaded: a salience detection system for the body. Prog Neurobiol. 2011;93(1):111-124. doi:10.1016/j.pneurobio.2010.10.005

  17. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci U S A. 2001;98(2):676-682. doi:10.1073/pnas.98.2.676

  18. Hebb DO. The Organization of Behavior: A Neuropsychological Theory. New York: Wiley; 1949.

  19. Moseley GL, Vlaeyen JW. Beyond nociception: the imprecision hypothesis of chronic pain. Pain. 2015;156(1):35-38. doi:10.1016/j.pain.0000000000000014

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